Destiny is a hard thing to live up to sometimes, especially when you're born with incredible powers. The Guardians of Tirisfal are a line of champions infused with god-like powers, given the responsibility to fight a war against the Burning Legions of the Horde. Khadgar the mage is sent by the Violet Citadel to master mage Medivh as an apprentice, but quickly learns much more than he ever counted on. Medivh is the last of the Guardians, and carries with him a deep struggle - his soul was corrupted by darkness from birth in such a way that ultimately will weave his destiny with that of the very land of Azeroth.
| Aegwynn | Very beautiful. A Guardian distinguished as a mighty warrior against the Horde; mother of Medivh. Second to last Guardian of Tirisfal, she is near 1,000 years old in Cycle of Hatred. | Realm | Cycle of Hatred |
| Alonda | Requests Khadgar examine Medivh's beastiaries, convinced there are five races of trolls, not four. (Khadgar didn't find any others.) | none | |
| Aran | Nielas | Thin, narrow-faced, with a slender moustache and goatee. Court conjurer and advisor for Azeroth's king, we see him in flashback form during the Last Guardian on the morning after his affair with Aegwynn that resulting in Medivh's birth. | none | Cycle of Hatred |
| Arrexis | A great sage of Dalaran that disappeared in such a horrible way most references of him were stricken from records. | none | |
| Borton | | Commander under King Llane | none | |
| Cook | Also a resident of Medivh's tower, in possession of rose-quartz glasses to also be undisturbed by 'visions'. (deceased) | none | |
| Deadeye | Kilrogg | Bleeding Hollow clan leader | NPC, NPC, Realm | |
| Dealth | | Lady, scholar. Requests Khadgar find out all he could about elven history from his stay with Medivh. | none | |
| Gul'dan | Ner'zhul's apprentice, works with Medivh to bring orcs to Azeroth. Warlock of the Stormreaver clan | Realm | |
| Guzbah | First teacher of Khadgar. Most curious about history and the 'Song of Aegwynn'. (deceased) | none | |
| Halforcen | Garona | A mixture of orc and human, she possesses an affinity for wearing black, and has a mass of ebony hair. Garona is a half orc who is only known as the 'Emissary' when she is introduced as a guest of Medivh's. She works together with Khadgar to defeat a demon and Medivh. | Item, Realm | |
| Hugarin | | A mage destroyed in a reported attempt to conjure a demon along with Hulgar. (deceased) | none | |
| Hulgar | | A mage destroyed in a reported attempt to conjure a demon along with Hugarin. (deceased) | none | |
| Karazhan | An orc spellcaster. | none | |
| Korrigan | Librarian of the Violet Citadel with a secret collection of pamphlets describing demon worshipers. | none | |
| Llane | | Lively, blond haired gentleman. King of Azeroth, friend of Medivh and Lothar. As young men they would adventure through the kingdom on many legendary adventures. Garona sees a vision in the Last Guardian in which she betrays and kills him. He is based out of Stormwind. Favors an ax. | Realm | |
| Lothar | Anduin | He is one of the last descendents of the Arathi bloodline, a long time friend of Llane and Medivh. He is also known as the King's Champion. Favors a sword. | Realm | |
| Moroes | | Stooped, resembles a weasel. Steward to the tower, Castellan to Medivh. He offers Khadgar blinders to keep him from being troubled by 'visions'. (Khadgar refuses them.) (deceased) | none | |
| Norlan | | Chief Artificer of the Violet Citadel | none | |
| Sargeras | Great warrior of the Pantheon; A noble titan-giant of molten bronze, we see his defeat in the The Last Guardian by Aegwynn. | Realm | Cycle of Hatred, War of the Ancients |
